Microscopy and microanalysis study of the indium (In) behavior in the intestinal mucosa, the liver, the kidney and the testicle.
Identifieur interne : 001275 ( Main/Exploration ); précédent : 001274; suivant : 001276Microscopy and microanalysis study of the indium (In) behavior in the intestinal mucosa, the liver, the kidney and the testicle.
Auteurs : RBID : pubmed:21482664English descriptors
- KwdEn :
- Animals, Duodenum (chemistry), Duodenum (ultrastructure), Electron Probe Microanalysis, Enterocytes (chemistry), Enterocytes (ultrastructure), Hepatocytes (chemistry), Hepatocytes (ultrastructure), Indium (administration & dosage), Indium (analysis), Injections, Intraperitoneal, Intestinal Mucosa (chemistry), Intestinal Mucosa (ultrastructure), Kidney (chemistry), Kidney (ultrastructure), Liver (chemistry), Liver (ultrastructure), Lysosomes (chemistry), Lysosomes (ultrastructure), Male, Microscopy, Electron, Transmission, Rats, Rats, Wistar, Spectrometry, Mass, Secondary Ion, Testis (chemistry), Testis (ultrastructure).
- MESH :
- chemical , administration & dosage : Indium.
- chemical , analysis : Indium.
- chemistry : Duodenum, Enterocytes, Hepatocytes, Intestinal Mucosa, Kidney, Liver, Lysosomes, Testis.
- ultrastructure : Duodenum, Enterocytes, Hepatocytes, Intestinal Mucosa, Kidney, Liver, Lysosomes, Testis.
- Animals, Electron Probe Microanalysis, Injections, Intraperitoneal, Male, Microscopy, Electron, Transmission, Rats, Rats, Wistar, Spectrometry, Mass, Secondary Ion.
Abstract
Several studies have demonstrated that In used in medicine has several impacts on organs like spleen and lungs after its systemic administration. In the present study, ultrastructural and microanalytical methods were used to investigate the impact of the presence of this element in the intestinal mucosa, the liver, the kidney and the testicle after its administration in two ways. After intraperitoneal administration, In was selectively concentrated in the lysosomes of hepatocytes, of tubular proximal convoluted cells and of Sertoli and Leydig cells. After intragastric administration, ultrastructural study showed that this element was concentrated in the lysosomes of duodenal enterocytes. Microanalytical methods showed that In was precipitated in those organelles in the form of insoluble phosphate salts. Similarly to other studies, it seemed that since In is a foreign element for the organism, it was precipitated in lysosomes, very probably due to the activity of an intralysosomal enzyme the acid phosphatase, to avoid its invasion to organism via the blood. This mechanism of precipitation of the mineral elements is of great interest in the process of defensive reaction of the organism against intoxication by foreign elements.
DOI: 10.1093/jmicro/dfr009
PubMed: 21482664
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Microscopy and microanalysis study of the indium (In) behavior in the intestinal mucosa, the liver, the kidney and the testicle.</title><author><name sortKey="Maghraoui, Samira" uniqKey="Maghraoui S">Samira Maghraoui</name><affiliation wicri:level="1"><nlm:affiliation>Laboratoire de Physiologie, Faculté de Médecine de Tunis (Université de Tunis El Manar), 15, Rue Djebel Lakhdar, La Rabta 1007, Tunis, Tunisia. maghraoui.samira@gmail.com</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Laboratoire de Physiologie, Faculté de Médecine de Tunis (Université de Tunis El Manar), 15, Rue Djebel Lakhdar, La Rabta 1007, Tunis</wicri:regionArea></affiliation></author><author><name sortKey="Ayadi, Ahlem" uniqKey="Ayadi A">Ahlem Ayadi</name></author><author><name sortKey="Ben Ammar, Aouatef" uniqKey="Ben Ammar A">Aouatef Ben Ammar</name></author><author><name sortKey="Jaafoura, Mohamed Habib" uniqKey="Jaafoura M">Mohamed-Habib Jaafoura</name></author><author><name sortKey="El Hili, Ali" uniqKey="El Hili A">Ali El Hili</name></author><author><name sortKey="Galle, Pierre" uniqKey="Galle P">Pierre Galle</name></author><author><name sortKey="Tekaya, Leila" uniqKey="Tekaya L">Leila Tekaya</name></author></titleStmt><publicationStmt><date when="2011">2011</date><idno type="doi">10.1093/jmicro/dfr009</idno><idno type="RBID">pubmed:21482664</idno><idno type="pmid">21482664</idno><idno type="wicri:Area/Main/Corpus">001436</idno><idno type="wicri:Area/Main/Curation">001436</idno><idno type="wicri:Area/Main/Exploration">001275</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Duodenum (chemistry)</term><term>Duodenum (ultrastructure)</term><term>Electron Probe Microanalysis</term><term>Enterocytes (chemistry)</term><term>Enterocytes (ultrastructure)</term><term>Hepatocytes (chemistry)</term><term>Hepatocytes (ultrastructure)</term><term>Indium (administration & dosage)</term><term>Indium (analysis)</term><term>Injections, Intraperitoneal</term><term>Intestinal Mucosa (chemistry)</term><term>Intestinal Mucosa (ultrastructure)</term><term>Kidney (chemistry)</term><term>Kidney (ultrastructure)</term><term>Liver (chemistry)</term><term>Liver (ultrastructure)</term><term>Lysosomes (chemistry)</term><term>Lysosomes (ultrastructure)</term><term>Male</term><term>Microscopy, Electron, Transmission</term><term>Rats</term><term>Rats, Wistar</term><term>Spectrometry, Mass, Secondary Ion</term><term>Testis (chemistry)</term><term>Testis (ultrastructure)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Indium</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Indium</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Duodenum</term><term>Enterocytes</term><term>Hepatocytes</term><term>Intestinal Mucosa</term><term>Kidney</term><term>Liver</term><term>Lysosomes</term><term>Testis</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Duodenum</term><term>Enterocytes</term><term>Hepatocytes</term><term>Intestinal Mucosa</term><term>Kidney</term><term>Liver</term><term>Lysosomes</term><term>Testis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Electron Probe Microanalysis</term><term>Injections, Intraperitoneal</term><term>Male</term><term>Microscopy, Electron, Transmission</term><term>Rats</term><term>Rats, Wistar</term><term>Spectrometry, Mass, Secondary Ion</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several studies have demonstrated that In used in medicine has several impacts on organs like spleen and lungs after its systemic administration. In the present study, ultrastructural and microanalytical methods were used to investigate the impact of the presence of this element in the intestinal mucosa, the liver, the kidney and the testicle after its administration in two ways. After intraperitoneal administration, In was selectively concentrated in the lysosomes of hepatocytes, of tubular proximal convoluted cells and of Sertoli and Leydig cells. After intragastric administration, ultrastructural study showed that this element was concentrated in the lysosomes of duodenal enterocytes. Microanalytical methods showed that In was precipitated in those organelles in the form of insoluble phosphate salts. Similarly to other studies, it seemed that since In is a foreign element for the organism, it was precipitated in lysosomes, very probably due to the activity of an intralysosomal enzyme the acid phosphatase, to avoid its invasion to organism via the blood. This mechanism of precipitation of the mineral elements is of great interest in the process of defensive reaction of the organism against intoxication by foreign elements.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">21482664</PMID><DateCreated><Year>2011</Year><Month>04</Month><Day>12</Day></DateCreated><DateCompleted><Year>2011</Year><Month>08</Month><Day>04</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1477-9986</ISSN><JournalIssue CitedMedium="Internet"><Volume>60</Volume><Issue>2</Issue><PubDate><Year>2011</Year></PubDate></JournalIssue><Title>Journal of electron microscopy</Title><ISOAbbreviation>J Electron Microsc (Tokyo)</ISOAbbreviation></Journal><ArticleTitle>Microscopy and microanalysis study of the indium (In) behavior in the intestinal mucosa, the liver, the kidney and the testicle.</ArticleTitle><Pagination><MedlinePgn>183-90</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/jmicro/dfr009</ELocationID><Abstract><AbstractText>Several studies have demonstrated that In used in medicine has several impacts on organs like spleen and lungs after its systemic administration. In the present study, ultrastructural and microanalytical methods were used to investigate the impact of the presence of this element in the intestinal mucosa, the liver, the kidney and the testicle after its administration in two ways. After intraperitoneal administration, In was selectively concentrated in the lysosomes of hepatocytes, of tubular proximal convoluted cells and of Sertoli and Leydig cells. After intragastric administration, ultrastructural study showed that this element was concentrated in the lysosomes of duodenal enterocytes. Microanalytical methods showed that In was precipitated in those organelles in the form of insoluble phosphate salts. Similarly to other studies, it seemed that since In is a foreign element for the organism, it was precipitated in lysosomes, very probably due to the activity of an intralysosomal enzyme the acid phosphatase, to avoid its invasion to organism via the blood. This mechanism of precipitation of the mineral elements is of great interest in the process of defensive reaction of the organism against intoxication by foreign elements.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Maghraoui</LastName><ForeName>Samira</ForeName><Initials>S</Initials><Affiliation>Laboratoire de Physiologie, Faculté de Médecine de Tunis (Université de Tunis El Manar), 15, Rue Djebel Lakhdar, La Rabta 1007, Tunis, Tunisia. maghraoui.samira@gmail.com</Affiliation></Author><Author ValidYN="Y"><LastName>Ayadi</LastName><ForeName>Ahlem</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Ben Ammar</LastName><ForeName>Aouatef</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Jaafoura</LastName><ForeName>Mohamed-Habib</ForeName><Initials>MH</Initials></Author><Author ValidYN="Y"><LastName>El Hili</LastName><ForeName>Ali</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Galle</LastName><ForeName>Pierre</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Tekaya</LastName><ForeName>Leila</ForeName><Initials>L</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Japan</Country><MedlineTA>J Electron Microsc (Tokyo)</MedlineTA><NlmUniqueID>7611157</NlmUniqueID><ISSNLinking>0022-0744</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>045A6V3VFX</RegistryNumber><NameOfSubstance>Indium</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Duodenum</DescriptorName><QualifierName MajorTopicYN="N">chemistry</QualifierName><QualifierName MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Electron Probe Microanalysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Enterocytes</DescriptorName><QualifierName MajorTopicYN="N">chemistry</QualifierName><QualifierName MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Hepatocytes</DescriptorName><QualifierName MajorTopicYN="N">chemistry</QualifierName><QualifierName MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium</DescriptorName><QualifierName MajorTopicYN="N">administration & dosage</QualifierName><QualifierName MajorTopicYN="Y">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Injections, Intraperitoneal</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Intestinal Mucosa</DescriptorName><QualifierName MajorTopicYN="N">chemistry</QualifierName><QualifierName MajorTopicYN="Y">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Kidney</DescriptorName><QualifierName MajorTopicYN="N">chemistry</QualifierName><QualifierName MajorTopicYN="Y">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Liver</DescriptorName><QualifierName MajorTopicYN="N">chemistry</QualifierName><QualifierName MajorTopicYN="Y">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Lysosomes</DescriptorName><QualifierName MajorTopicYN="N">chemistry</QualifierName><QualifierName MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Microscopy, Electron, Transmission</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Rats, Wistar</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Spectrometry, Mass, Secondary Ion</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Testis</DescriptorName><QualifierName MajorTopicYN="N">chemistry</QualifierName><QualifierName MajorTopicYN="Y">ultrastructure</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>4</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>4</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>8</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">dfr009</ArticleId><ArticleId IdType="doi">10.1093/jmicro/dfr009</ArticleId><ArticleId IdType="pubmed">21482664</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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